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KMID : 1059520190630010007
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Journal of the Korean Chemical Society
2019 Volume.63 No. 1 p.7 ~ p.11
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Crystal Form of Olmutinib
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Lee Chang-Yeob
Sohn Young-Taek
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Abstract
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Olmutinib, N-[3-({2-[4-(4-methylpiperazine-1-yl)aniline]thieno[3,2-d]Pyrimidin-4-yl}oxy)phenyl]prop-2-enamide dihydrochloride monohydrate, OlitaTM is an oral, third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR TKI) that was developed by Boehringer Ingelheim and Hanmi Pharmaceutical Co. Ltd for the treatment of non-small cell lung cancer (NSCLC). The aim of this work was to investigate the existence of polymorphs and pseudopolymorphs of olmutinib. Three crystal forms of olmutinib have been isolated by recrystallization and characterized by differential scanning calorimetry (DSC), thermogravimetric (TG) analysis and powder X-ray diffractometry (PXRD). From the DSC and TG data it was confirmed that Form 1 is monohydrate, Form 2 is dihydrate, Form 3 is 1.5 hydrate. The PXRD patterns of three crystal forms were different respectively. After storage of 1 month at 2 oC, 24% RH (Relative Humidity), Form 1, Form 2, and Form 3 were not transformed.
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KEYWORD
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Olmutinib, Crystal form, DSC, TG, PXRD
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